Osteoarthritis is a degenerative joint injury, especially of older people, which is caused of cartilage damage. There is still no effective cartilage structure restoring treatment, though recently attention is paid to biological cartilage regeneration, using autologous chondrocyte implantation. In order to increase the effectiveness of treatment, it is necessary to improve procedures for cell isolation, cultivation, and growing on the scaffold. The project aims to develop and characterize the most effective 3D scaffold with animal (rabbit) and human cells. Results will be applied in search for an optimal type of scaffold and production methods.
Project funding:
Research Council of Lithuania (RCL), National Research Programme “Healthy Ageing”
Project results:
3D microstructured scaffold has been developed on which rabbit chondrocytes and human chondrogenic cells can be grown. Using these scaffolds, the ability of human stem cells to form cartilaginous tissue was assessed in vitro.
Period of project implementation: 2015-10-01 - 2018-05-31
Project coordinator: Lithuanian University of Health Sciences
Project partners: Vilnius University, Kaunas University of Technology
